Khalil Shakir is set for Week 1 as Buffalo hosts Baltimore in prime time. He posted 100 targets, 76 catches, 821 yards and 4 TD last season, finishing WR37 in PPR. With an ADP around 45, he’ll likely come off the bench for many, but could pay off as a high-usage flex in Week 1.

In a high-volume Bills passing attack, Shakir’s floor is solid in PPR and his ceiling hinges on game flow. Expect Allen to target him early and often, making him a trustworthy start in many fantasy lineups and a potential season-long sleeper if his target share grows again.

Week 1 fantasy pivots center on nine pass-catching options: Khalil Shakir, Michael Pittman Jr., Rashid Shaheed, Jayden Higgins, Marvin Mims Jr., Romeo Doubs, Luther Burden III, Kyle Williams and Deebo Samuel Sr. The focus is on week-by-week matchups, ceiling floors, snap shares and how the Who Should I Start? tool helps you decide among up to four players. Deebo Samuel Sr. stands out as a bounce-back candidate in Washington, with Pittman, Shaheed and Higgins presenting nuanced flex plays in deeper formats. Mims, Doubs, Burden III and Williams are long shots whose Week 1 roles hinge on usage and opponent.

Across the board, the article emphasizes balancing risk and upside: Pittman’s middling flex potential versus the Dolphins, Shaheed’s boom-or-bust WR4 profile, Higgins’ early-involvement in Houston, Mims’ full run with Denver, and Burden III’s rookie upside for Chicago. Shakir and Doubs sit in the mix as depth adds, while Deebo Samuel Sr. is the clearest high-floor option with WR3 upside. The Start/Sit tool updates projections and projections by scoring format, helping you optimize Week 1 lineups.

Use the tool to compare, then trust matchup-driven decisions to maximize Week 1 output. The focus remains concrete: find reliable flex options, identify potential breakout targets, and leverage efficient matchups to edge your Week 1 contests.

Khalil Shakir is positioned as Buffalo’s top pass catcher in Week 1 after Diggs’ departure, with the Bills’ offseason additions not materially threatening his target share. Shakir broke out in 2024 (76 receptions, 821 yards, 4 TDs on 100 targets) and enters 2025 with clear WR3/flex value in a high-octane Bills offense. An ankle scare in camp didn’t derail three straight full practices, setting him up for a favorable matchup against Baltimore’s playoff-caliber offense in a potential shootout.

Buffalo’s depth chart remains lean beyond Shakir, with Joshua Palmer adding veteran presence but not monopolizing targets. Josh Allen’s ceiling remains sky-high, and Shakir’s involvement should keep him in fantasy lineups as a strong flex in Week 1, especially in formats that reward catches and yards. Expect big-play upside and a hefty target floor if the Bills lean on him early against Baltimore.

Buffalo Bills vs. Baltimore Ravens — Week 1 injury notes shape a high-stakes fantasy outlook. Tyler Bass is out, replaced by Matt Prater; Tre'Davious White is questionable after not practicing; Christian Benford, Khalil Shakir, Elijah Moore and Keon Coleman could see expanded roles if White is limited. Baltimore lists Isiah Likely and Patrick Richard out; Daniel Faalele is questionable, with Jaire Alexander also on the questionable/return path.

Expect a game plan where Bills lean on pass-catching options to counter a potential Ravens secondary edge if Alexander suits up, while Ravens weigh how to deploy their pallette at tight end and backfield with Likely out. Kicking swings, WR utilization and line health will swing Week 1 fantasy expectations.